Category: Uncategorized
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The article describes two main types of epigenetic changes, referred to as chromatin modifications or chromatin marks. They specifically analyze post-translational modifications (PTMs) of histone proteins and the incorporation of histone variants. Chromatin modifications encompass a wide range of chemical changes to histones, including phosphorylation, acetylation, and methylation. This refers to the exchange of standard…
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This observational study investigated self-reported eye color across three generations of a primary family unit, supplemented by data from unrelated individuals. The initial assessment revealed variation in eye color, even within the core family, suggesting a complex inheritance pattern rather than a simple Mendelian model. The first generation (n=4) exhibited a spectrum of blue, green,…
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The communication of epidemiological statistics in genetic research carries significant weight, especially for conditions like Alzheimer’s disease, where public anxiety is high. The scientific review on the APOE gene and AD is a model of responsible communication because it is transparent about the limitations of its data. The primary limitation is generalizability; the measurements of…
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The Precision Medicine Initiative, which tailors treatment and prevention to an individual’s unique characteristics, represents a significant shift from traditional public health approaches. However, precision medicine both aligns with and conflicts with public health goals. Precision medicine offers powerful tools that align with the public health mission of disease prevention and health equity. By using…
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In criminology, forensic investigators have used DNA analysis for some time. They apply genetic analysis to solve crimes where biological materials serve as evidence. This type of analysis remains a powerful forensic tool despite its drawbacks. Advances in DNA testing have made it so precise and highly sensitive that handlers risk contaminating samples (Butler,…
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Genome-wide association studies (GWAS) attempt to identify genetic variations associated with specific traits or diseases across the human genome (Manolio, 2010). An effective GWAS typically requires dense marker coverage across the genome to capture patterns of genetic variation linked to the phenotype of interest. Genotype imputation is a statistical technique that is used to infer…
Nicholas Holmes Scientific Portfolio 